GAD67 (Glutamate Decarboxylase 67), encoded by the GAD1 gene, is an enzyme responsible for the synthesis of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. GAD67 plays a critical role in regulating neurotransmission and maintaining the balance between excitatory and inhibitory signals in the central nervous system. It is primarily expressed in GABAergic neurons and is involved in key processes such as mood regulation, motor control, and neural development. Dysregulation of GAD67 has been implicated in various neurological and psychiatric disorders, including schizophrenia and epilepsy.
参考文献
Feldblum, S. et al. (1993) J Neurosci Res 34, 689-706.
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