Immunohistochemistry (IHC): 1:1,000 Western Blotting (WB): 1:10,000
产品信息
Reactive Species
Human
Target UniProt ID
P19320
Target Alternative Names
Vascular cell adhesion protein 1, INCAM-100
Target Molecular Weight (kDa)
110 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
6L20
Expression System
CHO
Immunogen
Recombinant protein corresponding to the C-terminal , extracellular domain of human VCAM-1.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
VCAM-1 (Vascular Cell Adhesion Molecule 1) is an integral membrane protein primarily expressed on the surface of endothelial cells in response to inflammatory stimuli. It plays a critical role in leukocyte adhesion and migration during immune responses. VCAM-1 binds to VLA-4 (Very Late Antigen-4) on circulating leukocytes, facilitating their attachment to the endothelium and subsequent movement into tissues during inflammation. This process is vital for immune cell trafficking, particularly in conditions such as autoimmune diseases, inflammatory disorders, and atherosclerosis. VCAM-1 is also implicated in tumor metastasis and the progression of cardiovascular diseases, making it an important target in research on immune regulation and vascular health.
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