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Anti-SOD2 / MnSOD Recombinant Rabbit Monoclonal Ab
克隆号：1D15
ICC IHC WB
ERB0389
货号 规格 数量. 价格 库存
ERB0389-25μg 25μg
ERB0389-100μg 100μg
ERB0389-500μg 500μg
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应用 产品信息 背景 参考文献 相关产品
应用
Immunocytochemistry (ICC): 1:1,000
Immunohistochemistry (IHC): 1:100
Western Blotting (WB): 1:1,000
产品信息
Reactive Species Human, Rat
Target UniProt ID P04179
Target Alternative Names Superoxide dismutase [Mn], mitochondrial
Target Molecular Weight (kDa) 25 kDa
Sensitivity Endogenous
Host / lsotype Rabbit / IgG
Class Recombinant Antibody
Clone 1D15
Expression System CHO
Immunogen Recombinant protein of full-length human SOD2.
Purification Protein A
Conjugate Unconjugated
Form Liquid
Concentration 0.5 mg/mL
Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition -20°C
背景
SOD2 (Superoxide Dismutase 2), also known as manganese superoxide dismutase (MnSOD), is an important antioxidant enzyme found primarily in the mitochondria. It plays a crucial role in protecting cells from oxidative stress by catalyzing the conversion of harmful superoxide radicals (O₂⁻) into hydrogen peroxide (H₂O₂), which is then further detoxified by other antioxidant enzymes. This process helps to maintain cellular integrity and function, especially within the mitochondria, which are highly susceptible to oxidative damage. SOD2 is essential for maintaining mitochondrial health, energy production, and cellular signaling. Dysregulation of SOD2 has been linked to various diseases, including neurodegenerative disorders, cancer, and cardiovascular diseases, making it a critical target for research in oxidative stress and cellular defense mechanisms.
参考文献
Cooper, M.L. et al. (2008) Cancer Res 68, 10171-7.
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