Immunocytochemistry (ICC): 1:100 Immunohistochemistry (IHC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human, Mouse
Target UniProt ID
Q92769
Target Alternative Names
Histone deacetylase 2, HD2, Protein deacylase HDAC2
Target Molecular Weight (kDa)
55 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
1F20
Expression System
CHO
Immunogen
Synthetic peptide corresponding to the C-terminal region of human HDAC2.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
HDAC2 (Histone Deacetylase 2) is an enzyme that plays a key role in the regulation of gene expression through the modification of histones and other proteins. As a member of the histone deacetylase (HDAC) family, HDAC2 removes acetyl groups from the lysine residues of histones, leading to chromatin condensation and the suppression of gene transcription. This modification is essential for regulating cell differentiation, cell cycle progression, neurodevelopment, and synaptic plasticity. HDAC2 has been implicated in several diseases, including neurodegenerative disorders, cancer, and mental health conditions. Its role in gene repression and cellular regulation makes it a potential therapeutic target for conditions involving altered gene expression and cellular dysfunction.
参考文献
Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.
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