Programmed cell death protein 1, Protein PD-1 , PDCD1
Target Molecular Weight (kDa)
32 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
2G7
Expression System
CHO
Immunogen
Recombinant protein corresponding to the extracellular domain of human PD-1.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
PD-1 (Programmed Cell Death Protein 1) is an immune checkpoint receptor expressed on the surface of T cells, B cells, and other immune cells. It plays a critical role in regulating the immune response by inhibiting T cell activity to maintain immune homeostasis and prevent autoimmunity. PD-1 interacts with its ligands, PD-L1 and PD-L2, which are expressed on various cells, including tumor cells, and dampens immune responses. This interaction helps to regulate immune tolerance and prevent excessive inflammation. PD-1 has gained significant attention in cancer immunotherapy, as its inhibition can enhance immune responses against tumors, leading to the development of immune checkpoint inhibitors such as anti-PD-1 antibodies used in cancer treatment.
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