Immunocytochemistry (ICC): 1:10 Immunohistochemistry (IHC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human, Mouse, Rat (predicted)
Target UniProt ID
O43602
Target Alternative Names
Neuronal migration protein doublecortin, Doublin, Lissencephalin-X (Lis-X), DCX
Target Molecular Weight (kDa)
42 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
4G12
Expression System
CHO
Immunogen
Synthetic peptide corresponding to the C-terminal region of human Doublecortin.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
Doublecortin (DCX) is a microtubule-associated protein that plays a crucial role in neuronal migration and neurogenesis, particularly during brain development. It is highly expressed in neuroblasts and immature neurons and is essential for the proper organization and movement of these cells within the developing brain. DCX stabilizes microtubules and facilitates the structural integrity of neuronal processes, enabling cells to migrate to their appropriate locations in the cerebral cortex and other brain regions. Mutations in the DCX gene are linked to X-linked lissencephaly and subcortical band heterotopia, disorders characterized by abnormal neuronal migration and cortical malformations. The protein also plays a role in neuroplasticity and has been studied for its potential involvement in neurodegenerative diseases and brain repair.
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