Immunocytochemistry (ICC): 1:1,000 Immunohistochemistry (IHC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human, Mouse
Target UniProt ID
Q13887
Target Alternative Names
Krueppel-like factor 5, Basic transcription element-binding protein 2 (BTE-binding protein 2), Colon krueppel-like factor, GC-box-binding protein 2, Intestinal-enriched krueppel-like factor, Transcription factor BTEB2
Target Molecular Weight (kDa)
60 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
2K14
Expression System
CHO
Immunogen
Synthetic peptide corresponding to the C-terminal region of human KLF5.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
KLF5 (Kruppel-like factor 5) is a transcription factor that plays a critical role in regulating various biological processes, including cell proliferation, differentiation, and apoptosis. As a member of the Kruppel-like factor (KLF) family of transcription factors, KLF5 binds to specific DNA sequences to modulate the expression of genes involved in embryonic development, tissue homeostasis, and stem cell function. It is particularly important in the regulation of vascular smooth muscle cell differentiation and function, and has been implicated in the development of cancer, vascular diseases, and fibrosis. KLF5 is also involved in maintaining the balance between cell growth and cell death, making it an important player in both normal cellular processes and disease.
参考文献
Tetreault, M.P. et al. (2013) Nat Rev Cancer 13, 701-13.
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