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Anti-ATG7 Recombinant Rabbit Monoclonal Ab
克隆号：2F17
IHC WB
ERB0385
货号 规格 数量. 价格 库存
ERB0385-25μg 25μg
ERB0385-100μg 100μg
ERB0385-500μg 500μg
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应用 产品信息 背景 参考文献 相关产品
应用
Immunohistochemistry (IHC): 1:100
Western Blotting (WB): 1:1,000
产品信息
Reactive Species Human, Mouse, Rat
Target UniProt ID O95352
Target Alternative Names Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7 (APG7-like; hAGP7), Ubiquitin-activating enzyme E1-like protein
Target Molecular Weight (kDa) 65kDa
Sensitivity Endogenous
Host / lsotype Rabbit / IgG
Class Recombinant Antibody
Clone 2F17
Expression System CHO
Immunogen Synthetic peptide corresponding to the N-terminal region of human ATG7.
Purification Protein A
Conjugate Unconjugated
Form Liquid
Concentration 0.5 mg/mL
Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition -20°C
背景
ATG7 (Autophagy-related 7) is a key enzyme involved in the process of autophagy, a cellular mechanism responsible for degrading and recycling damaged or unnecessary cellular components. ATG7 plays a crucial role in the formation of autophagosomes, which are membrane-bound vesicles that encapsulate cellular debris for degradation. It acts as an essential E1-like enzyme in the autophagy pathway, facilitating the conjugation of LC3 (microtubule-associated protein 1 light chain 3) to phosphatidylethanolamine, a critical step in autophagosome formation. ATG7 is involved in various cellular processes, including cellular homeostasis, response to stress, immune function, and development. Dysregulation of ATG7 has been linked to several diseases, including neurodegenerative disorders, cancer, and immune system dysfunction.
参考文献
Levine, B. and Yuan, J. (2005) J Clin Invest 115, 2679-88.
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