Immunocytochemistry (ICC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human, Mouse, Rat
Target UniProt ID
O95140
Target Alternative Names
Transmembrane GTPase MFN2
Target Molecular Weight (kDa)
80 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
3F10
Expression System
CHO
Immunogen
Synthetic peptide corresponding to the C-terminal, cytoplasmic domain of human Mitofusin-2.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
Mitofusin-2 (MFN2) is a protein that plays a crucial role in the regulation of mitochondrial dynamics, particularly in the processes of mitochondrial fusion and network formation. It is located in the outer mitochondrial membrane and helps mediate the fusion of adjacent mitochondria, which is essential for maintaining mitochondrial function and energy production. MFN2 also participates in the regulation of mitochondrial morphology, cellular metabolism, and calcium homeostasis. Mutations in the MFN2 gene are associated with Charcot-Marie-Tooth disease, a genetic disorder that affects the peripheral nervous system. As a key player in mitochondrial maintenance, MFN2 is important for overall cellular health and function.
参考文献
Chan, D.C. (2006) Annu Rev Cell Dev Biol 22, 79-99.
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