Immunocytochemistry (ICC): 1:100 Immunohistochemistry (IHC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human, Mouse
Target UniProt ID
Q9H8Y5
Target Alternative Names
tRNA endonuclease ANKZF1, Ankyrin repeat and zinc finger domain-containing protein 1, Zinc finger protein 744
Target Molecular Weight (kDa)
110 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
2F5
Expression System
CHO
Immunogen
Synthetic peptide corresponding to the N-terminal region of human ANKZF1.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
tRNA endonuclease ANKZF1 is an enzyme that plays a crucial role in the processing of tRNA molecules. It is involved in cleaving the precursor tRNA molecules to generate mature tRNAs, which are essential for protein synthesis. ANKZF1 specifically recognizes and cleaves the 3' end of precursor tRNAs, a critical step in the maturation process. This enzyme is important for the proper functioning of the protein translation machinery and contributes to cellular RNA processing. Mutations in ANKZF1 have been implicated in certain genetic disorders, and the enzyme's role in tRNA maturation makes it a key player in maintaining the integrity of cellular translation and gene expression.
参考文献
Verma, R. et al. (2018) Nature. 557(7705):446-451.
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