Immunocytochemistry (ICC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human
Target UniProt ID
Q09472
Target Alternative Names
Histone acetyltransferase p300, E1A-associated protein p300, Histone butyryltransferase p300, Histone crotonyltransferase p300, Protein 2-hydroxyisobutyryltransferase p300, Protein lactyltransferas p300, Protein propionyltransferase p300, EP300
Target Molecular Weight (kDa)
280 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
5F6
Expression System
CHO
Immunogen
Recombinant protein corresponding to the N-terminal region of human p300.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
Histone Acetyltransferase p300 (p300) is a versatile transcriptional co-activator and histone acetyltransferase that plays a key role in regulating gene expression. It adds acetyl groups to histone proteins, which leads to chromatin relaxation and promotes gene transcription by allowing greater access to the DNA. p300 is involved in a wide range of cellular processes, including cell growth, differentiation, DNA repair, and apoptosis. Beyond its role in histone acetylation, p300 also interacts with a variety of transcription factors and co-regulators to modulate gene activity. It is essential in regulating both normal cellular functions and responses to stress, and its dysfunction has been implicated in a variety of diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
参考文献
Goodman, R.H. and Smolik, S. (2000) Genes Dev 14, 1553-77.
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