Anti-NMDAR2B / NMDA receptor 2B Recombinant Rabbit Monoclonal Ab

克隆号：6D19

应用:

ICC IHC WB

ERB0399

货号	规格	数量.	价格	库存
ERB0399-25μg	25μg
ERB0399-100μg	100μg
ERB0399-500μg	500μg

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应用产品信息背景参考文献相关产品

应用

Immunocytochemistry (ICC): 1:1,000
Immunohistochemistry (IHC): 1:1,000
Western Blotting (WB): 1:10,000

产品信息

Reactive Species	Mouse, Rat
Target UniProt ID	Q01097
Target Alternative Names	Glutamate receptor ionotropic, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B (NMDAR2B; NR2B), Grin2b
Target Molecular Weight (kDa)	166 kDa
Sensitivity	Endogenous
Host / lsotype	Rabbit / IgG
Class	Recombinant Antibody
Clone	6D19
Expression System	CHO
Immunogen	Synthetic peptide corresponding to the C-terminal region of murine NMDAR2B.
Purification	Protein A
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition	-20°C

背景

NMDA receptor 2B (NR2B), also known as GRIN2B, is a subunit of the NMDA receptor, a type of glutamate receptor that plays a crucial role in synaptic plasticity, learning, and memory. The NMDA receptor is a ligand-gated ion channel that allows the flow of calcium (Ca²⁺), sodium (Na⁺), and potassium (K⁺) ions into the cell in response to glutamate binding. NR2B is one of the key subunits of the receptor, contributing to its functional properties, including its ion conductance and kinetics. NR2B is predominantly expressed in the central nervous system and is particularly involved in neurodevelopmental processes and synaptic strengthening. Alterations in NR2B function have been linked to neurodegenerative diseases, psychiatric disorders, and learning impairments, making it an important target for research in these areas.

参考文献

Westphal, R.S. et al. (1999) Science 285, 93-6.

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