Immunocytochemistry (ICC): 1:100 Immunohistochemistry (IHC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human, Mouse, Rat
Target UniProt ID
P05067
Target Alternative Names
ABPP, APPI, Alzheimer disease amyloid A4 protein homolog, Alzheimer disease amyloid protein
Target Molecular Weight (kDa)
110 kDa
Sensitivity
Endogenous
Host / lsotype
Mouse / IgG1
Class
Recombinant Antibody
Clone
22C11-L
Expression System
CHO
Immunogen
Recombinant protein of APP A4.
Purification
Protein G
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
APP A4 (Amyloid Precursor Protein A4) is a precursor protein that is primarily expressed in neurons and is best known for its association with Alzheimer's disease. APP undergoes proteolytic cleavage by enzymes, such as secretases, resulting in the production of various fragments, including beta-amyloid (Aβ) peptides. These peptides can aggregate to form amyloid plaques, a hallmark feature of Alzheimer's disease. While APP A4 is implicated in neurodegeneration, it also plays a role in normal cellular processes like cell signaling, growth, and synaptic function. The study of APP and its cleaved products, particularly Aβ, is central to understanding the mechanisms underlying Alzheimer's disease and developing potential therapeutic strategies.
参考文献
Caporaso, G.L. et al. (1992) Proc Natl Acad Sci USA 89, 3055-9.
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