Anti-MIP-1b / CCL-4 Recombinant Mouse Monoclonal Ab

克隆号：6E1

应用:

Sandwich ELISA

EMS0031

货号	规格	数量.	价格	库存
EMS0031-25μg	25μg
EMS0031-100μg	100μg
EMS0031-500μg	500μg

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应用产品信息背景参考文献相关产品

应用

Sandwich ELISA detection antibody

产品信息

Reactive Species	Human
Target UniProt ID	P13236
Target Alternative Names	C-C motif chemokine 4. G-26 T-lymphocyte-secreted protein HC21 Lymphocyte activation gene 1 protein (LAG-1) MIP-1-beta(1-69) Macrophage inflammatory protein 1-beta (MIP-1-beta)
Target Molecular Weight (kDa)	8 kDa
Sensitivity	Endogenous
Host / lsotype	Mouse / IgG1
Class	Recombinant Antibody
Clone	6E1
Expression System	CHO
Immunogen	Recombinant protein of full-length human CCL4.
Purification	Protein G
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Storage Buffer	PBS, 0.05% BSA, 0.04% Proclin 300
Storage Condition	-20°C

背景

CCL4, also known as Macrophage Inflammatory Protein-1 beta (MIP-1β), is a chemokine involved in the immune response and inflammation. It is primarily produced by activated monocytes, macrophages, and T cells. CCL4 plays a critical role in recruiting immune cells, particularly T cells, monocytes, and dendritic cells, to sites of infection, injury, or inflammation. It binds to the CCR5 receptor, which is present on various immune cells, promoting their migration and activation. CCL4 is involved in both acute and chronic inflammatory conditions, including infections, autoimmune diseases, and cancer. Its ability to influence immune cell trafficking and activation makes it an important mediator in regulating immune responses.

参考文献

Mukaida, N. et al. (2020) Adv Exp Med Biol. 1231:23-32.

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