Full-length recombinant human p53-binding protein 1.
Purification
Protein G
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
53BP1 (p53-binding protein 1) is a crucial protein involved in the DNA damage response and the maintenance of genomic stability. It plays a key role in the repair of double-strand breaks in DNA by promoting the repair process through non-homologous end joining (NHEJ), a pathway essential for repairing damaged DNA in cells. 53BP1 functions by recognizing DNA damage sites, recruiting other repair proteins, and ensuring that the repair process is accurately carried out. In addition, 53BP1 interacts with the tumor suppressor protein p53, which is known for its role in regulating cell cycle progression and apoptosis. Due to its critical involvement in DNA repair and genome integrity, 53BP1 has been implicated in cancer development, with mutations or dysregulation of 53BP1 potentially contributing to tumorigenesis.
参考文献
Panier, S., and Boulton, S. (2014). Nat Rev Mol Cell Biol 15(1); 7-18
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