Recombinant protein corresponding to the internal region of human LAMC2.
Purification
Protein G
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
LAMC2 (Laminin subunit gamma-2) is a protein that is a critical component of the extracellular matrix, specifically as part of the laminin family of glycoproteins. It forms a heterotrimeric structure by combining with alpha and beta subunits to create laminin-5, which plays a vital role in cell adhesion, migration, and tissue organization. LAMC2 is predominantly expressed in epithelial cells, where it helps maintain the integrity of the basement membrane, which serves as a scaffold for tissue architecture. It is crucial for processes such as wound healing and tissue repair. Mutations in LAMC2 have been associated with various disorders, including epidermolysis bullosa, a skin condition characterized by fragile skin. Due to its involvement in maintaining cellular and tissue structure, LAMC2 is of significant interest in developmental biology and disease research.
参考文献
Miyazaki, K., et al. (2016). Cancer Sci. 107(12); 1909-1918
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