Immunocytochemistry (ICC): 1:100 Immunohistochemistry (IHC): 1:1,000 Western Blotting (WB): 1:50,000
产品信息
Reactive Species
Human, Mouse
Target UniProt ID
P02699 (Bovine) P08100 (Human)
Target Alternative Names
Opsin-2
Target Molecular Weight (kDa)
37 kDa
Sensitivity
Endogenous
Host / lsotype
Mouse / IgG1
Class
Recombinant Antibody
Clone
Rho 1D4-L
Expression System
CHO
Immunogen
Purified full-length Bovine Rhodopsin.
Purification
Protein G
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
Rhodopsin is a light-sensitive receptor protein found in the retina, primarily in the rod cells of the eye. It plays a crucial role in vision by enabling the detection of light, particularly in low-light conditions. Rhodopsin is a member of the G protein-coupled receptor (GPCR) family and consists of a protein component, opsin, bound to a light-absorbing molecule called retinal (a form of vitamin A). When rhodopsin absorbs photons of light, retinal undergoes a conformational change, triggering a cascade of biochemical events that ultimately send electrical signals to the brain, allowing for visual perception. Rhodopsin is vital for night vision and overall visual function, and defects in rhodopsin or its signaling pathways are associated with various visual disorders, including retinitis pigmentosa and other retinal degenerative diseases.
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