Immunohistochemistry (IHC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human, Mouse, Rat
Target UniProt ID
P28037
Target Alternative Names
Cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1, FBP-CI
Target Molecular Weight (kDa)
100 kDa
Sensitivity
Endogenous
Host / lsotype
Mouse / IgG1
Class
Recombinant Antibody
Clone
N103/39-L
Expression System
CHO
Immunogen
Full-length recombinant rat Aldh1L1.
Purification
Protein G
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
Aldh1L1 (Aldehyde dehydrogenase 1 family member L1) is an enzyme belonging to the aldehyde dehydrogenase (ALDH) superfamily. It plays a key role in cellular detoxification by catalyzing the oxidation of toxic aldehydes, such as formaldehyde and retinaldehyde, converting them into less harmful substances. Aldh1L1 is primarily expressed in the brain, particularly in astrocytes, and is involved in glutamate metabolism, which is crucial for maintaining the balance of excitatory neurotransmitters. Its activity is important for protecting neural cells from oxidative stress and damage. Additionally, Aldh1L1 has been studied in relation to neurodegenerative diseases, where its dysfunction may contribute to neuroinflammation and neuronal injury.
参考文献
Beyer, F., et al. (2021). Front. Neurosci. 15; 713077
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