Immunocytochemistry (ICC): 1:100
Immunohistochemistry (IHC): 1:100
Western Blotting (WB): 1:10,000
| Reactive Species | Human, Mouse |
|---|---|
| Target UniProt ID | O96028 |
| Target Alternative Names | Histone-lysine N-methyltransferase NSD2, Multiple myeloma SET domain-containing protein, Nuclear SET domain-containing protein 2, Protein trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein |
| Target Molecular Weight (kDa) | 70 kDa |
| Sensitivity | Endogenous |
| Host / lsotype | Mouse / IgG2b |
| Class | Recombinant Antibody |
| Clone | 29D1-L |
| Expression System | CHO |
| Immunogen | Recombinant protein of human WHSC1 / NSD2 |
| Purification | Protein G |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300 |
| Storage Condition | -20°C |
NSD2 (Nuclear Receptor Binding SET Domain Protein 2), also known as WHSC1, is a histone methyltransferase enzyme that plays a critical role in the regulation of gene expression by modifying histones, specifically by adding methyl groups to histone H3 at lysine 36 (H3K36). This modification is associated with gene activation, chromatin remodeling, and the regulation of transcriptional elongation. NSD2 is essential for proper cellular differentiation, development, and genomic stability. Mutations in the NSD2 gene have been linked to various diseases, including Wolf-Hirschhorn syndrome and certain types of cancers such as multiple myeloma, where NSD2 overexpression can contribute to tumorigenesis. Research on NSD2 focuses on understanding its role in gene regulation, chromatin dynamics, and its potential as a therapeutic target in cancer and other diseases.
仅供研究使用。不用于诊断程序。备案号：苏ICP备2025182204号-1
技术支持:库价化学
扫一扫添加
