2,2,7-Trimethylguanosine (TMG) is a modified guanine nucleotide found in the cap structure of eukaryotic mRNA. It is part of a post-transcriptional modification that occurs at the 5' end of the mRNA, where a 7-methylguanosine cap is added and further methylated at the 2' position of the ribose sugar, forming TMG. This modification is crucial for mRNA stability, nuclear export, and translation initiation, as the TMG cap protects mRNA from degradation and helps in the recognition of mRNA by the translation machinery. TMG modification is particularly important in eukaryotic cells and plays a key role in regulating gene expression and RNA processing.
参考文献
Moketi, S., et al. (2002). Mol Cell. 10(3):599-609. Krainer, A.R., et al. (1988). Nucleic Acids Res. 16(20):9415-9429. Yedavalli, YSRK., and Jeang, K-T. (2010). Proc. Natl. Acad. Sci. USA. 107(33); 14787-14792
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