Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand (APRIL), TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2), TNF-related death ligand 1 (TRDL-1), CD256
Target Molecular Weight (kDa)
22 kDa
Sensitivity
Endogenous
Host / lsotype
Mouse / IgG1λ
Class
Recombinant Antibody
Clone
13D2
Expression System
CHO
Immunogen
Recombinant protein of full-length human April.
Purification
Protein G
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
APRIL (A PRoliferation-Inducing Ligand) is a cytokine belonging to the tumor necrosis factor (TNF) superfamily. It plays a crucial role in the regulation of immune responses and the survival of B cells, which are essential for antibody production. APRIL binds to receptors such as BCMA (B-cell maturation antigen) and TACI (transmembrane activator and CAML interactor), influencing B cell proliferation, differentiation, and survival. Additionally, APRIL is involved in the regulation of immune tolerance and inflammation and has been implicated in various autoimmune diseases and cancers due to its effects on immune cell function and tissue responses.
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