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Anti-BAFF / BLyS / TNFSF13B Recombinant Mouse Monoclonal Ab
克隆号：6A1
Sandwich ELISA
EMS0261
货号 规格 数量. 价格 库存
EMS0261-25μg 25μg
EMS0261-100μg 100μg
EMS0261-500μg 500μg
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应用
Sandwich ELISA detection antibody
产品信息
Reactive Species Human
Target UniProt ID Q9Y275
Target Alternative Names Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator (BLyS), B-cell-activating factor, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1)
Target Molecular Weight (kDa) 19 kDa
Sensitivity Endogenous
Host / lsotype Mouse / IgG1
Class Recombinant Antibody
Clone 6A1
Expression System CHO
Immunogen Recombinant protein of full-length human BAFF.
Purification Protein G
Conjugate Unconjugated
Form Liquid
Concentration 0.5 mg/mL
Storage Buffer PBS, 0.05% BSA, 0.04% Proclin 300
Storage Condition -20°C
背景
BAFF (B-cell activating factor), also known as BLyS (B lymphocyte stimulator), is a cytokine that plays a critical role in the survival, activation, and differentiation of B cells. It is primarily produced by monocytes, dendritic cells, and stromal cells. BAFF is essential for maintaining the homeostasis of the B cell population, promoting B cell survival and maturation, and supporting the development of humoral immunity. By interacting with its receptors (BAFF-R, TACI, and BCMA) on B cells, BAFF regulates key processes such as B cell proliferation, class switching, and antibody production. Due to its importance in B cell function, BAFF is implicated in autoimmune diseases like systemic lupus erythematosus (SLE) and other B cell-driven pathologies.
参考文献
Moore, P.A. et al. (1999) Science 285:260.
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