| Reactive Species | Human, Mouse (predicted), Rat (predicted) |
|---|---|
| Target UniProt ID | P68431 |
| Target Alternative Names | H3K9, H3t, Histone H3 Ac Lysine 9 |
| Target Molecular Weight (kDa) | 16 kDa |
| Sensitivity | Endogenous |
| Host / lsotype | Rabbit / IgG |
| Class | Recombinant Antibody |
| Clone | 4F21 |
| Expression System | CHO |
| Immunogen | Synthetic peptide surrounding acetylated lysines 9 and 14 of human Histone H3. |
| Purification | Protein A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300 |
| Storage Condition | -20°C |
Acetyl Histone H3 (Lys 9 & 14) refers to the acetylation of specific lysine residues (Lys 9 and Lys 14) on the histone H3 protein, which is a core component of the nucleosome in eukaryotic cells. Acetylation of these lysines is a post-translational modification that plays a key role in regulating gene expression by altering the chromatin structure. When histone H3 is acetylated at these positions, it leads to a more relaxed chromatin conformation, making the DNA more accessible to the transcriptional machinery, thus promoting gene activation. This modification is often associated with active transcription and is considered a hallmark of gene activation. Acetylation at Lys 9 and Lys 14 is regulated by enzymes such as histone acetyltransferases (HATs) and histone deacetylases (HDACs), and it is an important marker in studies of epigenetic regulation and cellular processes like differentiation, development, and disease.
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技术支持:库价化学
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