Anti-ALDH1A1 Recombinant Rabbit Monoclonal Ab

克隆号：3K6

应用:

IHC WB

ERB0056

货号	规格	数量.	价格	库存
ERB0056-25μg	25μg
ERB0056-100μg	100μg
ERB0056-500μg	500μg

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应用产品信息背景参考文献相关产品

应用

Immunohistochemistry (IHC): 1:100
Western Blotting (WB): 1:1,000

产品信息

Reactive Species	Human, Mouse, Rat
Target UniProt ID	P00352
Target Alternative Names	Aldehyde dehydrogenase 1A1, 3-deoxyglucosone dehydrogenase, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase (cytosolic), Retinal dehydrogenase 1
Target Molecular Weight (kDa)	54 kDa
Sensitivity	Endogenous
Host / lsotype	Rabbit / IgG
Class	Recombinant Antibody
Clone	3K6
Expression System	CHO
Immunogen	Synthetic peptide corresponding to the C-terminal region of human ALDH1A1.
Purification	Protein A
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition	-20°C

背景

ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) is an enzyme that plays a crucial role in the metabolism of retinoids and detoxification of aldehydes. It is part of the aldehyde dehydrogenase (ALDH) family, which is involved in the conversion of toxic aldehydes into non-toxic carboxylic acids. ALDH1A1 is most notably involved in the oxidation of retinaldehyde to retinoic acid, an important step in the synthesis of retinoic acid, a key molecule in regulating gene expression, cell differentiation, and embryonic development. ALDH1A1 is also implicated in stem cell biology, as it is used as a marker for stem cells and cancer stem cells in various tissues, including breast, colon, and liver cancer. Additionally, ALDH1A1 plays a role in cellular protection by metabolizing reactive aldehydes generated under oxidative stress conditions. Its dysregulation is associated with cancer progression, drug resistance, and neurological disorders.

参考文献

Luo, Y. et al. (2012) Stem Cells 30, 2100-13.

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