Anti-Recoverin Recombinant Rabbit Monoclonal Ab
克隆号:2K22
ICC IHC WB
ERB0073
货号 规格 数量. 价格 库存
ERB0073-25μg 25μg
ERB0073-100μg 100μg
ERB0073-500μg 500μg
应用

Immunocytochemistry (ICC): 1:100
Immunohistochemistry (IHC): 1:250
Western Blotting (WB): 1:1,000

产品信息
Reactive Species Human
Target UniProt ID P35243
Target Alternative Names Cancer-associated retinopathy protein (Protein CAR), RCVRN
Target Molecular Weight (kDa) 21 kDa
Sensitivity Endogenous
Host / lsotype Rabbit / IgG
Class Recombinant Antibody
Clone 2K22
Expression System CHO
Immunogen Recombinant protein of full length human Recoverin.
Purification Protein A
Conjugate Unconjugated
Form Liquid
Concentration 0.5 mg/mL
Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition -20°C
背景

Recoverin is a calcium-binding protein primarily expressed in retinal cells, particularly in photoreceptors. It plays a key role in the regulation of visual signal transduction by modulating the activity of rhodopsin kinase, an enzyme involved in the phototransduction pathway. Recoverin acts as a calcium sensor, influencing the ability of photoreceptor cells to respond to light stimuli, thus contributing to visual adaptation and the ability to process light signals efficiently. Its function is crucial for maintaining the sensitivity of the retina, and defects in recoverin have been linked to certain retinal disorders.

参考文献

Polans, A.S. et al. (1995) PNAS 92(20):9176.