Anti-ABCG2 / BCRP Recombinant Rabbit Monoclonal Ab

克隆号：8K4

应用:

ICC IHC WB

ERB0095

货号	规格	数量.	价格	库存
ERB0095-25μg	25μg
ERB0095-100μg	100μg
ERB0095-500μg	500μg

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应用产品信息背景参考文献相关产品

应用

Immunocytochemistry (ICC): 1:100
Immunohistochemistry (IHC): 1:1,000
Western Blotting (WB): 1:1,000

产品信息

Reactive Species	Human, Mouse
Target UniProt ID	Q9UNQ0
Target Alternative Names	Broad substrate specificity ATP-binding cassette transporter ABCG2, ATP-binding cassette sub-family G member 2, Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338
Target Molecular Weight (kDa)	72 kDa
Sensitivity	Endogenous
Host / lsotype	Rabbit / IgG
Class	Recombinant Antibody
Clone	8K4
Expression System	CHO
Immunogen	Recombinant protein corresponding to the N-terminal region of human BCRP.
Purification	Protein A
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition	-20°C

背景

ABCG2, also known as Breast Cancer Resistance Protein (BCRP), is a member of the ATP-binding cassette (ABC) transporter family. It plays a key role in the efflux of a wide range of substrates, including drugs, toxins, and metabolic products, across cellular membranes. ABCG2 is widely expressed in various tissues such as the intestinal epithelium, liver, placenta, kidneys, and blood-brain barrier, where it contributes to the protection of the body by limiting the absorption of harmful compounds. In cancer cells, overexpression of ABCG2 is associated with multidrug resistance, as it can pump out chemotherapy drugs, reducing their efficacy. ABCG2 is also involved in regulating the pharmacokinetics of many therapeutic agents, making it an important target in drug development and cancer treatment strategies.

参考文献

Doyle, L.A. et al. (1998) Proc Natl Acad Sci U S A 95, 15665-70.

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