Anti-14-3-3 β/α Recombinant Rabbit Monoclonal Ab
克隆号:1G5
WB
ERB0177
货号 规格 数量. 价格 库存
ERB0177-25μg 25μg
ERB0177-100μg 100μg
ERB0177-500μg 500μg
应用

Western Blotting (WB): 1:10,000

产品信息
Reactive Species Human, Monkey, Rat (predicted)
Target UniProt ID P31946
Target Alternative Names Protein 1054 Protein kinase C inhibitor protein 1 (KCIP-1)
Target Molecular Weight (kDa) 28 kDa
Sensitivity Endogenous
Host / lsotype Rabbit / IgG
Class Recombinant Antibody
Clone 1G5
Expression System CHO
Immunogen Synthetic peptide corresponding to the C-terminal region of human 14-3-3 β/α.
Purification Protein A
Conjugate Unconjugated
Form Liquid
Concentration 0.5 mg/mL
Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition -20°C
背景

14-3-3 β/α is a member of the 14-3-3 protein family, which consists of highly conserved regulatory proteins involved in a variety of cellular processes. 14-3-3 β/α (also known as 14-3-3β or 14-3-3α) functions primarily as a molecular scaffold that interacts with and regulates numerous target proteins by binding to phosphoserine or phosphothreonine motifs. This interaction affects critical cellular functions such as signal transduction, cell cycle regulation, apoptosis, and stress response. 14-3-3 β/α is involved in modulating the activity of key signaling pathways, including those related to protein kinases and phosphatases. Dysregulation of 14-3-3 β/α has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases, making it an important target for ongoing research in cell signaling and therapeutic development.

参考文献

Muslin, A.J. and Xing, H. (2000) Cell Signal 12, 703-9.