Immunocytochemistry (ICC): 1:100 Immunohistochemistry (IHC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human, Mouse
Target UniProt ID
Q12888
Target Alternative Names
TP53-binding protein 1, TP53BP1
Target Molecular Weight (kDa)
270 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
1G15
Expression System
CHO
Immunogen
Recombinant protein corresponding to the N-terminal region of human 53BP1.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
53BP1 (TP53-binding protein 1) is a crucial protein involved in the cellular response to DNA damage and the maintenance of genomic stability. It plays a central role in the repair of double-strand breaks (DSBs), particularly through the non-homologous end joining (NHEJ) repair pathway. 53BP1 interacts with the tumor suppressor protein p53 and other DNA repair factors, coordinating the repair of damaged DNA and ensuring the proper functioning of cell cycle checkpoints. By stabilizing DNA damage sites, 53BP1 also regulates cell fate decisions, including cell survival and apoptosis. Given its role in genomic integrity, 53BP1 is implicated in the development of cancers and neurodegenerative diseases, where defects in DNA repair mechanisms can lead to mutations and genomic instability.
参考文献
Iwabuchi, K. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 6098-102.
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