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Anti-Tuberin / TSC2 Recombinant Rabbit Monoclonal Ab
克隆号：5K12
ICC IHC WB
ERB0340
货号 规格 数量. 价格 库存
ERB0340-25μg 25μg
ERB0340-100μg 100μg
ERB0340-500μg 500μg
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应用 产品信息 背景 参考文献 相关产品
应用
Immunocytochemistry (ICC): 1:100
Immunohistochemistry (IHC): 1:100
Western Blotting (WB): 1:1,000
产品信息
Reactive Species Human
Target UniProt ID P49815
Target Alternative Names Tuberous sclerosis 2 protein
Target Molecular Weight (kDa) 200 kDa
Sensitivity Endogenous
Host / lsotype Rabbit / IgG
Class Recombinant Antibody
Clone 5K12
Expression System CHO
Immunogen Synthetic peptide corresponding to the C-terminal region of human TSC2 .
Purification Protein A
Conjugate Unconjugated
Form Liquid
Concentration 0.5 mg/mL
Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition -20°C
背景
Tuberin (also known as TSC2, or Tuberous Sclerosis Complex 2) is a key protein that functions as a tumor suppressor and plays a critical role in the regulation of cell growth, proliferation, and autophagy. Tuberin forms a complex with another protein called TSC1 (hamartin), and together they regulate the activity of the mTOR (mechanistic target of rapamycin) signaling pathway. This pathway is essential for controlling cellular metabolism, protein synthesis, and organismal growth. Tuberin acts to inhibit mTOR activity, thereby suppressing excessive cell growth and division. Mutations or loss of TSC2 can lead to the development of tuberous sclerosis complex (TSC), a genetic disorder characterized by benign tumors in multiple organs, including the brain, kidneys, and heart. Tuberin is also implicated in neurological disorders, cancer, and metabolic diseases, making it a key target for ongoing research in cell signaling and disease therapeutics.
参考文献
Soucek, T. et al. (1998) Proc Natl Acad Sci U S A 95, 15653-8.
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