Immunocytochemistry (ICC): 1:100 Immunohistochemistry (IHC): 1:100 Western Blotting (WB): 1:1,000
产品信息
Reactive Species
Human
Target UniProt ID
P16112
Target Alternative Names
Aggrecan core protein, Cartilage-specific proteoglycan core protein (CSPCP), Chondroitin sulfate proteoglycan core protein 1 (Chondroitin sulfate proteoglycan 1), ACAN
Target Molecular Weight (kDa)
300 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
5C12
Expression System
CHO
Immunogen
Synthetic peptide corresponding to the N-terminal region of human Aggrecan.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
Aggrecan is a large, extracellular matrix proteoglycan primarily found in cartilage. It plays a critical role in maintaining the structural integrity and function of cartilage by providing it with the ability to withstand compressive forces. Aggrecan is composed of a core protein attached to glycosaminoglycan (GAG) chains, such as chondroitin sulfate and keratan sulfate, which attract water and contribute to the gel-like consistency of the cartilage matrix. This protein is essential for joint function and shock absorption, and its degradation is linked to various joint disorders, including osteoarthritis. Aggrecan is a key component in maintaining the mechanical properties and resilience of cartilage in the body.
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