Protein argonaute-2, Argonaute2, Argonaute RISC catalytic component 2, Eukaryotic translation initiation factor 2C 2(eIF-2C2), PAZ Piwi domain protein (PPD), Protein slicer
Target Molecular Weight (kDa)
97 kDa
Sensitivity
Endogenous
Host / lsotype
Rabbit / IgG
Class
Recombinant Antibody
Clone
3B9
Expression System
CHO
Immunogen
Synthetic peptide corresponding to the N-terminal region of human AGO2.
Purification
Protein A
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage Buffer
PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition
-20°C
背景
Argonaute 2 (AGO2) is a crucial protein involved in the RNA interference (RNAi) pathway, which regulates gene expression by controlling the stability and translation of specific mRNAs. As a core component of the RNA-induced silencing complex (RISC), AGO2 binds to small RNA molecules like microRNAs (miRNAs) and small interfering RNAs (siRNAs), guiding them to their target mRNA molecules. AGO2 then facilitates the cleavage or translational repression of these mRNAs, thereby controlling the expression of genes. This protein is essential for regulating various biological processes, including development, cell differentiation, immune response, and viral defense. Dysregulation of AGO2 activity has been implicated in cancer, neurodegenerative diseases, and viral infections, making it a critical target for research in gene regulation and disease mechanisms.
参考文献
Peters, L. and Meister, G. (2007) Mol Cell 26, 611-23.
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