Anti-Adrenomedullin / ADM Recombinant Rabbit Monoclonal Ab

克隆号：3N20

应用:

IHC WB

ERB0396

货号	规格	数量.	价格	库存
ERB0396-25μg	25μg
ERB0396-100μg	100μg
ERB0396-500μg	500μg

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应用产品信息背景参考文献相关产品

应用

Immunohistochemistry (IHC): 1:100
Western Blotting (WB): 1:1,000

产品信息

Reactive Species	Human
Target UniProt ID	P35318
Target Alternative Names	Pro-adrenomedullin
Target Molecular Weight (kDa)	20 kDa
Sensitivity	Endogenous
Host / lsotype	Rabbit / IgG
Class	Recombinant Antibody
Clone	3N20
Expression System	CHO
Immunogen	Synthetic peptide corresponding to the N-terminal region of human ADM.
Purification	Protein A
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.04% Proclin 300
Storage Condition	-20°C

背景

Adrenomedullin is a peptide hormone that plays a key role in regulating vascular tone, blood pressure, and fluid balance. It was first discovered in the adrenal medulla, but it is also produced in various tissues throughout the body, including the endothelium, heart, and kidneys. Adrenomedullin exerts its effects by binding to specific receptors, triggering the activation of signaling pathways that promote vasodilation, diuresis, and natriuresis, which help lower blood pressure and regulate the cardiovascular system. Additionally, adrenomedullin is involved in processes such as wound healing, immune responses, and cellular growth. Its dysregulation has been implicated in a range of cardiovascular diseases, including heart failure, hypertension, and sepsis.

参考文献

Tsuruda, T. et al. (2019) Peptides. 111:47-54.

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